{"id":1025,"date":"2022-10-17T12:59:57","date_gmt":"2022-10-17T12:59:57","guid":{"rendered":"https:\/\/mpelembe.net\/?p=1025"},"modified":"2022-10-17T12:59:57","modified_gmt":"2022-10-17T12:59:57","slug":"alzheimers-disease-surprising-new-theory-about-what-might-cause-it","status":"publish","type":"post","link":"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/","title":{"rendered":"Alzheimer\u2019s disease: surprising new theory about what might cause\u00a0it"},"content":{"rendered":"

Andrea Sturchio<\/a>, Karolinska Institutet<\/a><\/em>; Kariem Ezzat<\/a>, Karolinska Institutet<\/a><\/em>, and Samir EL Andaloussi<\/a>, Karolinska Institutet<\/a><\/em><\/span><\/p>\n

In 1906, Alois Alzheimer, a psychiatrist and neuroanatomist, reported<\/a> \u201ca peculiar severe disease process of the cerebral cortex\u201d to a gathering of psychiatrists in T\u00fcbingen, Germany. The case was a 50-year-old woman who suffered from memory loss, delusions, hallucinations, aggression and confusion \u2013 all of which worsened until her untimely death five years later. <\/p>\n

<\/p>\n

In the autopsy, Alzheimer noticed distinctive plaques on her brain. These plaques \u2013 clumps of amyloid-beta protein \u2013 are still considered to be the cause of Alzheimer\u2019s disease. <\/p>\n

However, this theory has two major problems. First, it does not explain why many subjects (even old people) have plaques in their brains in the absence of any neurological symptoms, such as memory loss. Second, clinical trials for drugs that reduce these plaques have been unsuccessful \u2013 with one recent exception<\/a>, but more of that later.<\/p>\n

When amyloid-beta protein accumulates in the form of plaques (insoluble clumps), the original soluble form of the protein, which performs important functions in the brain, is consumed and lost. Some studies have shown that reduced levels of soluble amyloid-beta \u2013 called amyloid-beta 42 \u2013 have led to patients having worse clinical outcomes.<\/p>\n

In a recent study<\/a>, published in the Journal of Alzheimer\u2019s Disease, we investigated whether it\u2019s the amount of plaques in the brain or the amount of amyloid-beta 42 remaining that is more important for Alzheimer\u2019s disease progression. <\/p>\n

To answer this question, we studied data on a group of people who have a rare inherited gene mutation that puts them at high risk of developing Alzheimer\u2019s disease. The participants were from the Dominantly Inherited Alzheimer Network<\/a> cohort study.<\/p>\n

We found that the depletion of amyloid-beta 42 (the functional version of amyloid-beta) is more harmful than the amount of plaques (the insoluble clumps of amyloid beta).<\/p>\n

Participants had an average of three years follow-up and we found that those with high levels of amyloid-beta 42 in their cerebrospinal fluid (the liquid around the brain and spinal cord) were protected and their cognition was preserved over the study period. This chimes with many studies that showed important functions of amyloid-beta 42 in memory and cognition<\/a>.<\/p>\n

It is also relevant because we studied people with the genetic mutation who develop Alzheimer\u2019s disease, a group that is considered to provide the strongest evidence supporting the idea that amyloid-beta plaques are harmful. However, even in this group, those with higher cerebronspinal fluid (CSF) levels of amyloid-beta 42 remained cognitively normal regardless of the amount of plaques in their brains. <\/p>\n

It is also worth mentioning that in some rare, inherited forms of Alzheimer\u2019s disease \u2013 for example, in carriers of the so-called Osaka gene mutation or Arctic mutation \u2013 people can develop dementia having low levels of amyloid-beta 42 and no detectable plaques. This suggests that plaques aren\u2019t the cause of their dementia, but low levels of amyloid-beta 42 might be. <\/p>\n

Lecanemab \u2013 the one recent exception<\/h2>\n

How will our findings affect drug development and clinical trials for Alzheimer\u2019s disease? Until the recent trial with lecanemab<\/a>, an antibody drug that reduces plaques, all the drug trials in Alzheimer\u2019s disease have failed. <\/p>\n

Some drugs were designed to reduce the levels of amyloid-beta 42, based on the rationale that if levels of the normal protein are reduced, patients will accumulate fewer plaques. Unfortunately, these drugs often made the patient\u2019s condition worse<\/a>.<\/p>\n

Lecanemab was recently reported to have a small but significant effect in reducing cognitive decline. According to previous studies<\/a>, this drug increases the levels of amyloid-beta 42 in the CSF. This is, again, in line with our hypothesis, namely that the increase of the normal amyloid protein can be beneficial. <\/p>\n

We will know more when the results of the lecanemab trial are published. At the moment, all we have is a press release<\/a> from the makers of the drug.<\/p>\n

We think that it will be important for future trials to focus on the levels of amyloid-beta 42, and whether it is beneficial to increase and restore its levels to normal values instead of targeting it for removal. This could be achieved using proteins similar to amyloid-beta 42 \u2013 so-called \u201cprotein analogues\u201d \u2013 but that clump together less than the natural ones. <\/p>\n

This active protein replacement approach might become a promising new avenue of treatment for Alzheimer\u2019s and other protein aggregation diseases, such as Parkinson\u2019s and motor neuron disease.\"The<\/p>\n

Andrea Sturchio<\/a>, MD, PhD Student, Clinical Neuroscience, Karolinska Institutet<\/a><\/em>; Kariem Ezzat<\/a>, Research Scientist, Laboratory Medicine, Karolinska Institutet<\/a><\/em>, and Samir EL Andaloussi<\/a>, Professor, Laboratory Medicine, Karolinska Institutet<\/a><\/em><\/span><\/p>\n

This article is republished from The Conversation<\/a> under a Creative Commons license. Read the original article<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Andrea Sturchio, Karolinska Institutet; Kariem Ezzat, Karolinska Institutet, and Samir EL Andaloussi, Karolinska Institutet In 1906, Alois Alzheimer, a psychiatrist and neuroanatomist, reported \u201caRead More…<\/a><\/p>\n","protected":false},"author":1,"featured_media":1026,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAowu7GVCw:productID":"","_crdt_document":"","activitypub_content_warning":"","activitypub_content_visibility":"","activitypub_max_image_attachments":3,"activitypub_interaction_policy_quote":"anyone","activitypub_status":"","footnotes":""},"categories":[21],"tags":[2450,2437,2443,2441,2438,2453,2448,2445,72,73,722,890,2440,2444,2447,2449,2439,1102,2442,2452,2446,2451],"class_list":["post-1025","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reasearch","tag-alois-alzheimer","tag-alzheimers-disease","tag-amyloid","tag-amyloid-beta","tag-amyloidosis","tag-andaloussi","tag-andrea-sturchio","tag-biochemistry-of-alzheimers-disease","tag-biology","tag-branches-of-biology","tag-creative-commons","tag-germany","tag-histopathology","tag-insulin-degrading-enzyme","tag-kariem-ezzat","tag-lecanemab","tag-molecular-neuroscience","tag-osaka","tag-peptides","tag-samir-el-andaloussi","tag-senile-plaques","tag-tubingen"],"featured_image_src":"https:\/\/mpelembe.net\/wp-content\/uploads\/2022\/10\/unnamed-6.jpg","blog_images":{"medium":"https:\/\/mpelembe.net\/wp-content\/uploads\/2022\/10\/unnamed-6-300x223.jpg","large":"https:\/\/mpelembe.net\/wp-content\/uploads\/2022\/10\/unnamed-6.jpg"},"ams_acf":[],"yoast_head":"\nAlzheimer\u2019s disease: surprising new theory about what might cause\u00a0it - Mpelembe Network<\/title>\n<meta name=\"description\" content=\"Too much amyloid-beta in the brain has long been considered the cause of Alzheimer\u2019s. New research suggests it might be the opposite.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s disease: surprising new theory about what might cause\u00a0it - Mpelembe Network\" \/>\n<meta property=\"og:description\" content=\"Too much amyloid-beta in the brain has long been considered the cause of Alzheimer\u2019s. New research suggests it might be the opposite.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/\" \/>\n<meta property=\"og:site_name\" content=\"Mpelembe Network\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-17T12:59:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mpelembe.net\/wp-content\/uploads\/2022\/10\/unnamed-6.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"668\" \/>\n\t<meta property=\"og:image:height\" content=\"496\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/mpelembe.net\\\/index.php\\\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/mpelembe.net\\\/index.php\\\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\\\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\\\/\\\/mpelembe.net\\\/#\\\/schema\\\/person\\\/2421ebbf3150931b1066b10a196d7608\"},\"headline\":\"Alzheimer\u2019s disease: surprising new theory about what might cause\u00a0it\",\"datePublished\":\"2022-10-17T12:59:57+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/mpelembe.net\\\/index.php\\\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\\\/\"},\"wordCount\":777,\"image\":{\"@id\":\"https:\\\/\\\/mpelembe.net\\\/index.php\\\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mpelembe.net\\\/wp-content\\\/uploads\\\/2022\\\/10\\\/unnamed-6.jpg\",\"keywords\":[\"Alois Alzheimer\",\"Alzheimer's disease\",\"Amyloid\",\"Amyloid beta\",\"Amyloidosis\",\"Andaloussi\",\"Andrea Sturchio\",\"Biochemistry of Alzheimer's disease\",\"Biology\",\"Branches of biology\",\"Creative Commons\",\"Germany\",\"Histopathology\",\"Insulin-degrading enzyme\",\"Kariem Ezzat\",\"Lecanemab\",\"Molecular neuroscience\",\"Osaka\",\"Peptides\",\"Samir EL Andaloussi\",\"Senile plaques\",\"T\u00fcbingen\"],\"articleSection\":[\"Reasearch\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/mpelembe.net\\\/index.php\\\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\\\/\",\"url\":\"https:\\\/\\\/mpelembe.net\\\/index.php\\\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\\\/\",\"name\":\"Alzheimer\u2019s disease: surprising new theory about what might cause\u00a0it - Mpelembe Network\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/mpelembe.net\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/mpelembe.net\\\/index.php\\\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/mpelembe.net\\\/index.php\\\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mpelembe.net\\\/wp-content\\\/uploads\\\/2022\\\/10\\\/unnamed-6.jpg\",\"datePublished\":\"2022-10-17T12:59:57+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/mpelembe.net\\\/#\\\/schema\\\/person\\\/2421ebbf3150931b1066b10a196d7608\"},\"description\":\"Too much amyloid-beta in the brain has long been considered the cause of Alzheimer\u2019s. New research suggests it might be the opposite.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/mpelembe.net\\\/index.php\\\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/mpelembe.net\\\/index.php\\\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/mpelembe.net\\\/index.php\\\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\\\/#primaryimage\",\"url\":\"https:\\\/\\\/mpelembe.net\\\/wp-content\\\/uploads\\\/2022\\\/10\\\/unnamed-6.jpg\",\"contentUrl\":\"https:\\\/\\\/mpelembe.net\\\/wp-content\\\/uploads\\\/2022\\\/10\\\/unnamed-6.jpg\",\"width\":668,\"height\":496},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/mpelembe.net\\\/index.php\\\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/mpelembe.net\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Alzheimer\u2019s disease: surprising new theory about what might cause\u00a0it\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/mpelembe.net\\\/#website\",\"url\":\"https:\\\/\\\/mpelembe.net\\\/\",\"name\":\"Mpelembe Network\",\"description\":\"Collaboration Platform\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/mpelembe.net\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/mpelembe.net\\\/#\\\/schema\\\/person\\\/2421ebbf3150931b1066b10a196d7608\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c66a2765397adfb52418f6f2310640167a0af23ce662da1b68c8a0b8650de556?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c66a2765397adfb52418f6f2310640167a0af23ce662da1b68c8a0b8650de556?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c66a2765397adfb52418f6f2310640167a0af23ce662da1b68c8a0b8650de556?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\\\/\\\/mpelembe.net\"],\"url\":\"https:\\\/\\\/mpelembe.net\\\/index.php\\\/author\\\/admin\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Alzheimer\u2019s disease: surprising new theory about what might cause\u00a0it - Mpelembe Network","description":"Too much amyloid-beta in the brain has long been considered the cause of Alzheimer\u2019s. New research suggests it might be the opposite.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/","og_locale":"en_US","og_type":"article","og_title":"Alzheimer\u2019s disease: surprising new theory about what might cause\u00a0it - Mpelembe Network","og_description":"Too much amyloid-beta in the brain has long been considered the cause of Alzheimer\u2019s. New research suggests it might be the opposite.","og_url":"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/","og_site_name":"Mpelembe Network","article_published_time":"2022-10-17T12:59:57+00:00","og_image":[{"width":668,"height":496,"url":"https:\/\/mpelembe.net\/wp-content\/uploads\/2022\/10\/unnamed-6.jpg","type":"image\/jpeg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"admin","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/#article","isPartOf":{"@id":"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/"},"author":{"name":"admin","@id":"https:\/\/mpelembe.net\/#\/schema\/person\/2421ebbf3150931b1066b10a196d7608"},"headline":"Alzheimer\u2019s disease: surprising new theory about what might cause\u00a0it","datePublished":"2022-10-17T12:59:57+00:00","mainEntityOfPage":{"@id":"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/"},"wordCount":777,"image":{"@id":"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/#primaryimage"},"thumbnailUrl":"https:\/\/mpelembe.net\/wp-content\/uploads\/2022\/10\/unnamed-6.jpg","keywords":["Alois Alzheimer","Alzheimer's disease","Amyloid","Amyloid beta","Amyloidosis","Andaloussi","Andrea Sturchio","Biochemistry of Alzheimer's disease","Biology","Branches of biology","Creative Commons","Germany","Histopathology","Insulin-degrading enzyme","Kariem Ezzat","Lecanemab","Molecular neuroscience","Osaka","Peptides","Samir EL Andaloussi","Senile plaques","T\u00fcbingen"],"articleSection":["Reasearch"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/","url":"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/","name":"Alzheimer\u2019s disease: surprising new theory about what might cause\u00a0it - Mpelembe Network","isPartOf":{"@id":"https:\/\/mpelembe.net\/#website"},"primaryImageOfPage":{"@id":"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/#primaryimage"},"image":{"@id":"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/#primaryimage"},"thumbnailUrl":"https:\/\/mpelembe.net\/wp-content\/uploads\/2022\/10\/unnamed-6.jpg","datePublished":"2022-10-17T12:59:57+00:00","author":{"@id":"https:\/\/mpelembe.net\/#\/schema\/person\/2421ebbf3150931b1066b10a196d7608"},"description":"Too much amyloid-beta in the brain has long been considered the cause of Alzheimer\u2019s. New research suggests it might be the opposite.","breadcrumb":{"@id":"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/#primaryimage","url":"https:\/\/mpelembe.net\/wp-content\/uploads\/2022\/10\/unnamed-6.jpg","contentUrl":"https:\/\/mpelembe.net\/wp-content\/uploads\/2022\/10\/unnamed-6.jpg","width":668,"height":496},{"@type":"BreadcrumbList","@id":"https:\/\/mpelembe.net\/index.php\/alzheimers-disease-surprising-new-theory-about-what-might-cause-it\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mpelembe.net\/"},{"@type":"ListItem","position":2,"name":"Alzheimer\u2019s disease: surprising new theory about what might cause\u00a0it"}]},{"@type":"WebSite","@id":"https:\/\/mpelembe.net\/#website","url":"https:\/\/mpelembe.net\/","name":"Mpelembe Network","description":"Collaboration Platform","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mpelembe.net\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/mpelembe.net\/#\/schema\/person\/2421ebbf3150931b1066b10a196d7608","name":"admin","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/c66a2765397adfb52418f6f2310640167a0af23ce662da1b68c8a0b8650de556?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c66a2765397adfb52418f6f2310640167a0af23ce662da1b68c8a0b8650de556?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c66a2765397adfb52418f6f2310640167a0af23ce662da1b68c8a0b8650de556?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/mpelembe.net"],"url":"https:\/\/mpelembe.net\/index.php\/author\/admin\/"}]}},"_links":{"self":[{"href":"https:\/\/mpelembe.net\/index.php\/wp-json\/wp\/v2\/posts\/1025","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mpelembe.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mpelembe.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mpelembe.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mpelembe.net\/index.php\/wp-json\/wp\/v2\/comments?post=1025"}],"version-history":[{"count":1,"href":"https:\/\/mpelembe.net\/index.php\/wp-json\/wp\/v2\/posts\/1025\/revisions"}],"predecessor-version":[{"id":1027,"href":"https:\/\/mpelembe.net\/index.php\/wp-json\/wp\/v2\/posts\/1025\/revisions\/1027"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mpelembe.net\/index.php\/wp-json\/wp\/v2\/media\/1026"}],"wp:attachment":[{"href":"https:\/\/mpelembe.net\/index.php\/wp-json\/wp\/v2\/media?parent=1025"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mpelembe.net\/index.php\/wp-json\/wp\/v2\/categories?post=1025"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mpelembe.net\/index.php\/wp-json\/wp\/v2\/tags?post=1025"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}